Kinesin molecular motor Eg5 functions during polypeptide synthesis
نویسندگان
چکیده
The kinesin-related molecular motor Eg5 plays roles in cell division, promoting spindle assembly. We show that during interphase Eg5 is associated with ribosomes and is required for optimal nascent polypeptide synthesis. When Eg5 was inhibited, ribosomes no longer bound to microtubules in vitro, ribosome transit rates slowed, and polysomes accumulated in intact cells, suggesting defects in elongation or termination during polypeptide synthesis. These results demonstrate that the molecular motor Eg5 associates with ribosomes and enhances the efficiency of translation.
منابع مشابه
coTitle: Kinesin Molecular Motor Eg5 Functions During the Elongation Phase of Polypeptide Synthesis
The kinesin-‐related molecular motor Eg5 plays a well-‐defined role in cell division, promoting spindle assembly, but here we show that during interphase Eg5 primarily associated with ribosomes and both Eg5 and the microtubule cytoskeleton were required for optimal nascent polypeptide ...
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